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Antibacterial effects against Proteus mirabilis, Salmonella typhimurium, and Aeromonas hydrophila were obtained with subminimal inhibitory concentrations of oxytetracycline and EDTA-tromethamine. Antibacterial effects were not observed with subminimal inhibitory concentrations of dimethyl sulfoxide plus oxytetracycline or with dimethyl sulfoxide plus EDTA-tromethamine. Using a 2-dimensional Microtiter checkerboard technique, inhibitory activities of the various combinations of solutions were studied, and isobolograms were plotted. A synergistic effect was seen with combinations of oxytetracycline and EDTA-tromethamine. The greatest synergistic effect was observed when the mixture was caused to react with P mirabilis. These findings were confirmed by kinetic studies of microbial death, using one-fourth minimal inhibitory concentrations of these preparations.
R E Wooley, and
J P Gilbert, and
E B Shotts
August 1974,
Antibiotiki,
R E Wooley, and
J P Gilbert, and
E B Shotts
October 1975,
American journal of veterinary research,
R E Wooley, and
J P Gilbert, and
E B Shotts
March 1968,
Japanese journal of pharmacology,
R E Wooley, and
J P Gilbert, and
E B Shotts
December 1969,
Archiv fur Hygiene und Bakteriologie,
R E Wooley, and
J P Gilbert, and
E B Shotts
May 1988,
American journal of surgery,
R E Wooley, and
J P Gilbert, and
E B Shotts
May 1971,
Radiation research,
R E Wooley, and
J P Gilbert, and
E B Shotts
January 1966,
Surgical forum,
R E Wooley, and
J P Gilbert, and
E B Shotts
January 1973,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
R E Wooley, and
J P Gilbert, and
E B Shotts
January 1971,
Archiv fur Geschwulstforschung,
R E Wooley, and
J P Gilbert, and
E B Shotts
June 1983,
Veterinary microbiology,
