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The acute haemodynamic effects of beta-blockade with propranolol and combined alpha-blockade and beta-blockade with labetalol were compared in a randomised study in 12 patients with coronary artery disease proved by angiography. Propranolol induced significantly greater depression of left ventricular function both at rest and during exercise than labetalol. This difference was probably attributable to the vasodilator activity of labetalol and the associated reduction in afterload offsetting the haemodynamic disadvantages of blockade of cardiac beta-adrenoceptors alone. The haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone may thus have therapeutic implications for the use of these treatments in patients with coronary heart disease.
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
October 1970,
Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
March 1996,
The American journal of cardiology,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
October 1987,
Journal of cardiovascular pharmacology,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
September 1987,
Fortschritte der Medizin,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
June 1982,
British journal of clinical pharmacology,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
January 1982,
Acta medica Scandinavica. Supplementum,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
January 1981,
Acta medica Scandinavica. Supplementum,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
October 1984,
British heart journal,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
January 1984,
Drugs,
S H Taylor, and
B Silke, and
G I Nelson, and
R C Okoli, and
R C Ahuja
October 1989,
International journal of cardiology,
