Biomaterial Database

Effects of various inhalation modes on the deposition of radioactive pressurized aerosols. 1982

S P Newman, and D Pavia, and N Garland, and S W Clarke

The deposition of aerosol consisting of Teflon particles (mass median aerodynamic diameter 3.2 micrometers) labelled with 99Tcm has been measured in patients with obstructive airways disease. Aerosol was inhaled at 30 l min-1 with 4 s breath holding (patient group A) and at 30 l min-1 with 10 s breath holding (patient group B). A further group of patients (group C) inhaled at 90 l min-1 with 10 s breath holding. Each subject was given the aerosol during inhalation at three different lung volumes (20% VC, 50% VC and 80% VC) on three different days. The greatest whole lung, tracheobronchial and alveolar depositions occurred in group B patients, irrespective of the lung volume of aerosol actuation. By comparison, deposition was similar in groups A and C only when the aerosol was actuated at 20% VC. Whole lung deposition in groups A and B was significantly correlated both with the bronchodilator response to terbutaline sulphate aerosol administered under the same inhalation conditions and with the residence time of airborne particles in the respiratory tract. The optimum inhalation technique for a beta-adrenergic aerosol indicated by these data (slow inhalation with 10 s breath holding) confirms the results of previous studies.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008173	Lung Diseases, Obstructive	Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.	Obstructive Lung Diseases,Obstructive Pulmonary Diseases,Lung Disease, Obstructive,Obstructive Lung Disease,Obstructive Pulmonary Disease,Pulmonary Disease, Obstructive,Pulmonary Diseases, Obstructive
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010316	Particle Size	Relating to the size of solids.	Particle Sizes,Size, Particle,Sizes, Particle
D011138	Polytetrafluoroethylene	Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.	FEP,Fluon,Politef,Polytef,TFE,Teflon,Expanded PTFE,Fluoroplast,GORE-TEX,Goretex,PTFE,Tarflen,GORE TEX,PTFE, Expanded
D011312	Pressure	A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Pressures
D012138	Respiratory Therapy	Care of patients with deficiencies and abnormalities associated with the cardiopulmonary system. It includes the therapeutic use of medical gases and their administrative apparatus, environmental control systems, humidification, aerosols, ventilatory support, bronchopulmonary drainage and exercise, respiratory rehabilitation, assistance with cardiopulmonary resuscitation, and maintenance of natural, artificial, and mechanical airways.	Inhalation Therapy,Therapy, Inhalation,Therapy, Respiratory,Inhalation Therapies,Respiratory Therapies,Therapies, Inhalation,Therapies, Respiratory
D001993	Bronchodilator Agents	Agents that cause an increase in the expansion of a bronchus or bronchial tubes.	Bronchial-Dilating Agents,Bronchodilator,Bronchodilator Agent,Broncholytic Agent,Bronchodilator Effect,Bronchodilator Effects,Bronchodilators,Broncholytic Agents,Broncholytic Effect,Broncholytic Effects,Agent, Bronchodilator,Agent, Broncholytic,Agents, Bronchial-Dilating,Agents, Bronchodilator,Agents, Broncholytic,Bronchial Dilating Agents,Effect, Bronchodilator,Effect, Broncholytic,Effects, Bronchodilator,Effects, Broncholytic
D005260	Female		Females