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The influence of a single intramuscular injection of estradiol benzoate (E2B), 2.5-15 micrograms/kg, on the basal estradiol, LH and FSH and their response to LRH stimulation (50 micrograms/m2, i.v.) performed 20 h after E2B injection, was studied in 52 normal boys aged 6-16 9/12 years. The minimal effective dose of E2B was found to be 10 micrograms/kg. This same dose of E2B which increased plasma estradiol level from 15 +/- 8 to 22 +/- 15 pg/ml (mean +/- SD) at 20 h after the intramuscular injection, suppressed basal plasma LH and FSH and their response to LRH in the prepubertal (n = 12), early-pubertal (n = 12) and late-pubertal (n = 8) boys. It is suggested that the maturation of the hypothalamo-pituitary axis in boys during puberty is under the influence of endogenous estradiol.
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
January 1972,
Journal of animal science,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
November 1974,
The Journal of clinical endocrinology and metabolism,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
August 1991,
Endocrinology,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
May 1974,
Endocrinology,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
March 1976,
The Journal of clinical endocrinology and metabolism,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
November 1975,
Archiv fur Gynakologie,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
January 1982,
Acta endocrinologica,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
August 1977,
Obstetrics and gynecology,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
February 1984,
Neuroendocrinology,
Z Dickerman, and
R Gurewitz, and
S Peleg, and
R Keret, and
A Gidali, and
Z Laron
September 1981,
Science (New York, N.Y.),
