Biomaterial Database

Absence of formation of cerebrospinal fluid in the spinal subarachnoid space of the cat. 1978

A Hamer, and A Sahar

It is widely believed that formation of cerebrospinal fluid (CSF) takes place within the cerebral ventricles--80 to 85% being produced by the choroid plexus and the remaining 15 to 20% being secreted by the lining ependyma. It has also been suggested that CSF is formed within the subarachnoid space. To investigate this possibility. CSF formation was measured in the isolated subarachnoid space of the cat. In 16 animals that underwent 26 steady-state perfusions, the rate of formation of CSF was found to be only 0.00005 +/- 0.00056 (SE) ml/min. It is therefore concluded that little or no CSF is formed in the spinal subarachnoid space of the cat.

UI	MeSH Term	Description	Entries
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D011312	Pressure	A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Pressures
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002555	Cerebrospinal Fluid	A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.	Cerebro Spinal Fluid,Cerebro Spinal Fluids,Cerebrospinal Fluids,Fluid, Cerebro Spinal,Fluid, Cerebrospinal,Fluids, Cerebro Spinal,Fluids, Cerebrospinal,Spinal Fluid, Cerebro,Spinal Fluids, Cerebro
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013346	Subarachnoid Space	The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.	Space, Subarachnoid,Spaces, Subarachnoid,Subarachnoid Spaces