Biomaterial Database

Animal models for the study of Chlamydial infections of the urogenital tract. 1982

B R Møller, and P A Mårdh

Various experimental animal models have been used for the study of chlamydial infections of the urogenital tract. Experimental urethral and vaginal inoculation of guinea pigs with the guinea-pig inclusion conjunctivitis agent provoke urogenital infection. Direct inoculation of this agent into the uterine horns of guinea pigs induced an acute self-limiting salpingitis. In cats, urethritis and vaginitis have been produced with the feline keratoconjunctivitis agent. The results obtained by using the grivet monkey as an animal model for the study of chlamydial infections of the urogenital tract indicate that Chlamydia trachomatis is able to cause inflammation of the urethra, the spermatic cord, and the epididymis of male grivet monkeys. In female grivet monkeys, the organism can cause inflammation of the cervix, the endometrium, and the fallopian tubes. In some cases, tubal occlusion can be demonstrated several weeks after the inoculation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002690	Chlamydia Infections	Infections with bacteria of the genus CHLAMYDIA.	Infections, Chlamydia,Chlamydia Infection,Infection, Chlamydia
D002691	Chlamydophila psittaci	A genus of CHLAMYDOPHILA infecting primarily birds. It contains eight known serovars, some of which infect more than one type of host, including humans.	Chlamydia psittaci
D002692	Chlamydia trachomatis	Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260	Female		Females
D005831	Genital Diseases, Female	Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).	Gynecologic Diseases,Female Genital Diseases,Diseases, Female Genital,Diseases, Gynecologic,Female Genital Disease,Genital Disease, Female,Gynecologic Disease
D005832	Genital Diseases, Male	Pathological processes involving the male reproductive tract (GENITALIA, MALE).	Male Genital Diseases,Disease, Male Genital,Diseases, Male Genital,Genital Disease, Male,Male Genital Disease
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea