-transparent.png){kind=logo}
Glia maturation factor (GMF)-like activity which induces DNA synthesis and morphological differentiation of density-inhibited glioblasts was detected in various glial tumor cells. A polypeptide from C6 cells (rat astrocytoma) which has a molecular weight range of 40,000-50,000 showed the highest activity. This factor also induced DNA synthesis in glioma cells (354A and LRM55) and fibroblast (Swiss 3T3). The activity was susceptible to heat treatment at 70 degrees C for 5 min, or to proteases such as trypsin, chymotrypsin, papain, and subtilisin, but it was devoid of esteropeptidase activity. The isoelectric point was found to be 5.3. Subcellular fractionation localized the activity in cytosomal and microsomal fractions. These properties closely resemble those of GMF from pig and bovine brain.
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
May 1987,
Brain research,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
May 1986,
Brain research,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
January 1987,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
January 2018,
Die Pharmazie,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
January 2007,
Anticancer research,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
January 1980,
Current topics in developmental biology,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
December 1984,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
January 1987,
Journal de physiologie,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
June 1997,
Endocrine,
Y Yamakawa, and
T Kato, and
Y Sakazaki, and
H Kato, and
Y Yamakawa, and
H Tsunooka, and
A Masaoka, and
D E Turriff, and
R Tanaka
November 2006,
Molecular endocrinology (Baltimore, Md.),
