-transparent.png){kind=logo}
The effect on glucose metabolism of altering the site of the venous drainage of an isograft of isolated adult islets implanted beneath the renal capsule, from the systemic circulation to the portal circulation was determined in streptozotocin-induced diabetic rats. Reversal of diabetes was accomplished by the transplantation of 1000-1200 isolated islets beneath the left kidney capsule. The rate of fall of the glucose concentration (as expressed by the K value) was found to be significantly decreased in transplanted animals (1.7 +/- 0.5%/min; mean +/- SD) compared with normal animals (2.4 +/- 0.5%/min). Draining the left renal vein into the portal circulation restored the K value to that of normal animals (2.5 +/- 0.4%). However the fasting glucose concentration was significantly higher and the basal insulin levels lower in both normal and transplanted rats with a renoportal shunt.
H Reece-Smith, and
P McShane, and
P J Morris
January 2003,
Cell transplantation,
H Reece-Smith, and
P McShane, and
P J Morris
May 2009,
Archives of physiology and biochemistry,
H Reece-Smith, and
P McShane, and
P J Morris
February 1992,
Transplantation proceedings,
H Reece-Smith, and
P McShane, and
P J Morris
July 1993,
Nippon Ganka Gakkai zasshi,
H Reece-Smith, and
P McShane, and
P J Morris
January 1994,
Cell transplantation,
H Reece-Smith, and
P McShane, and
P J Morris
January 1997,
Cell transplantation,
H Reece-Smith, and
P McShane, and
P J Morris
May 1979,
Fortschritte der Medizin,
H Reece-Smith, and
P McShane, and
P J Morris
March 1996,
The Journal of clinical investigation,
H Reece-Smith, and
P McShane, and
P J Morris
December 1973,
Diabetologia,
H Reece-Smith, and
P McShane, and
P J Morris
March 1990,
Diabetes,
