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The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes. Diabetic blood p50 was higher (29.79 +/- 1.68 versus 28.26 +/- 1.16 mmHg, p less than 0.001) and with a higher 2,3-diphosphoglyceric acid/haemoglobin molar ratio (1.04 +/- 0.15 versus 0.86 +/- 0.10, p less than 0.001). The pH at a pCO2 of 45 mmHg was the same in the two groups. The observed p50 values were compared with those obtained after normalization in respect to pH and the level of 2,3-diphosphoglyceric acid. We conclude that glycosylated haemoglobins, known to have an increased affinity for oxygen when purified and in diluted solutions, do not play a significant role in the oxygen affinity pattern of diabetics at the concentrations normally found in vivo.
M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
December 1981,
Diabetologia,
M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
December 1983,
Diabetologia,
M Samaja, and
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G Pozza
September 1976,
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M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
October 1982,
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M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
February 1983,
Clinica chimica acta; international journal of clinical chemistry,
M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
October 1973,
Respiration physiology,
M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
January 1980,
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M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
July 1977,
Lancet (London, England),
M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
October 1978,
Lancet (London, England),
M Samaja, and
D Melotti, and
A Carenini, and
G Pozza
May 1983,
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