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Hapten (fluorescein isothiocyanate, FITC)-sensitized syngeneic red blood cells (FITC-RBC) are exceptionally active for induction of anti-hapten primary antibody response, and FITC-modified syngeneic spleen cells depleted of RBC (FITC-SSC) are not immunogenic [4]. The present study has demonstrated that FITC-SSC injected simultaneously with FITC-RBC inhibit partially the anti-FITC response to the latter. Either the immunogenicity of FITC-RBC or the response-inhibiting activity of FITC-SSC was increased as the concentration of hapten-sensitizing cells was raised from 0.005 mg/ml to 2 mg/ml. The inhibition of anti-FITC response by FITC-SSC strictly required live donor cells, but was not dependent on T-cell activity of either the donor or recipient. Neither FITC-thymocytes nor the FITC-T-cell-rich fraction of SSC showed a definite activity for inhibition, whereas the FITC-B-cell-rich fraction of SSC acted very effectively. These results suggest that the primary anti-hapten antibody response to hapten-modified syngeneic cells is primarily controlled by antigen-bearing live donor cells of different cell types.
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
November 1981,
European journal of immunology,
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
December 1986,
European journal of immunology,
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
October 1987,
Cellular immunology,
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
July 2004,
Analytical biochemistry,
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
December 2000,
Analytical biochemistry,
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
November 1971,
European journal of immunology,
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
January 1981,
Scandinavian journal of immunology,
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
September 1982,
Journal of immunology (Baltimore, Md. : 1950),
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
February 1976,
Journal of immunology (Baltimore, Md. : 1950),
K Suzuki, and
I Nakashima, and
M Takashi, and
F Nagase, and
N Kato, and
K Isobe, and
K Mizoguchi, and
M Saito
January 1975,
Transplantation reviews,
