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A new ultrastructural cytoplasmic marker designated as type 2, and distinct from type 1 previously associated with NA-NB hepatitis in chimpanzees, was found in hepatocytes of two patients and of one experimentally infected chimpanzee. These cases represent a minority of all cases we studied as presumed NA-NB viral hepatitis. Type 2 marker consists of tubular structures composed of an assembly of ring-like units coated with smaller uniform fragments, accumulated in different patterns in dilated cisternae of the endoplasmic reticulum. Preliminary data using immunofluorescence with NA-NB hepatitis convalescent serum and antiserum against fibrinogen are reported. Type 2 marker may represent a different agent or a different reaction pattern to one agent of NA-NB viral hepatitis. Its features are compared with those of hepatitis B.
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
January 2002,
Vojnosanitetski pregled,
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
March 1983,
Scandinavian journal of gastroenterology,
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
January 1985,
Voprosy virusologii,
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
January 1984,
Journal of medical virology,
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
June 1979,
Lancet (London, England),
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
June 1982,
The Journal of infectious diseases,
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
March 1984,
Gastroenterologie clinique et biologique,
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
January 1982,
Voprosy virusologii,
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
April 1979,
Harefuah,
R De Vos, and
C De Wolf-Peeters, and
M J Van Stapel, and
F Callea, and
G De Groote, and
J Desmyter, and
J Mortelmans, and
J Fevery, and
J De Groote, and
V J Desmet
June 1985,
Nihon rinsho. Japanese journal of clinical medicine,
