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Bolus injections of synthetic thyrotropin-releasing hormone (TRH) were administered to five young normal men in the morning (0900 hr) and the evening (1800 hr) on different days. Frequent blood samples for prolactin (PRL) and TSH analyses were collected before and after TRH infusion. Although there were no differences between the morning and the evening basal PRL levels, a significantly greater PRL response to TRH in the evening was observed (delta PRL, a.m. vs p.m., p less than 0.025). Since TRH stimulates PRL through a direct effect on the pituitary, our data suggest that there is a diurnal variation in the pituitary lactotroph responsiveness to TRH. On the other hand, a.m. and p.m. basal and TRH-stimulated TSH responses were virtually identical.
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
July 1984,
Biological psychiatry,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
January 1984,
Psychosomatic medicine,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
October 1990,
The Journal of clinical endocrinology and metabolism,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
August 1977,
The Journal of clinical endocrinology and metabolism,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
February 1998,
American journal of veterinary research,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
February 1981,
The Journal of clinical endocrinology and metabolism,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
January 1986,
The American journal of the medical sciences,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
April 1984,
The Journal of clinical endocrinology and metabolism,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
January 1981,
Acta medica Scandinavica,
R S Nathan, and
E J Sachar, and
M A Tabrizi, and
G M Asnis, and
U Halbreich, and
F S Halpern
January 1973,
The Journal of clinical endocrinology and metabolism,
