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The behavioral effects of cholinergic agonists and antagonists were examined in two lines of rats which have been developed through selective breeding techniques to be differentially sensitive to the anticholinesterase diisopropyl fluorophosphate (DFP). The line of rats which were determined to be more sensitive to DFP (Flinders S line) were also more sensitive to the depressant effects of the agonists pilocarpine and physostigmine on locomotor activity, water intake, and operant responding maintained by water reward. In contrast, the locomotor stimulant effects of scopolamine, a muscarinic antagonist, were less marked in the S-line rats, while the depressant effects of atropine and scopolamine on water intake and operant responding maintained by water reward were comparable in the two lines. The S-line rats were also significantly more sensitive to the hypothermic effects of pilocarpine and oxotremorine. These findings are consistent with the hypothesis that the S-line rats are more sensitive to the acute effects of DFP because they have a higher number of muscarinic-cholinergic receptors.
D H Overstreet, and
R W Russell
January 1987,
Proceedings of the Western Pharmacology Society,
D H Overstreet, and
R W Russell
January 1982,
Acta haematologica,
D H Overstreet, and
R W Russell
October 1988,
Pharmacology, biochemistry, and behavior,
D H Overstreet, and
R W Russell
July 1987,
Applied and environmental microbiology,
D H Overstreet, and
R W Russell
March 2007,
Toxicology and applied pharmacology,
D H Overstreet, and
R W Russell
May 1953,
Arzneimittel-Forschung,
D H Overstreet, and
R W Russell
July 1948,
Science (New York, N.Y.),
D H Overstreet, and
R W Russell
January 1991,
Psychopharmacology,
D H Overstreet, and
R W Russell
February 1956,
Annali di ottalmologia e clinica oculistica,
D H Overstreet, and
R W Russell
November 1946,
Archives of ophthalmology (Chicago, Ill. : 1929),
