Biomaterial Database

[The bursa of Fabricius of chickens contains cells initiating the graft-versus-host reaction]. 1982

J Désveaux-Chabrol, and F Dieterlen-Lièvre

Allogeneic bursal fragments or bursal cells (B 14 or B 19), grafted on the chorioallantois, induce splenomegaly in the recipient embryo (B 14 or B 19). This splenomegaly compares to that instigated by spleen cells. Syngeneic bursal grafts do not result in spleen enlargement. The reaction is thus caused by the MHC difference of the two lines used. We conclude that B cells may have a role in initiating the GVH-R.

UI	MeSH Term	Description	Entries
D002060	Bursa of Fabricius	An epithelial outgrowth of the cloaca in birds similar to the thymus in mammals. It atrophies within 6 months after birth and remains as a fibrous remnant in adult birds. It is composed of lymphoid tissue and prior to involution, is the site of B-lymphocyte maturation.	Fabricius Bursa
D002642	Chick Embryo	The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.	Embryo, Chick,Chick Embryos,Embryos, Chick
D006087	Graft vs Host Reaction	An immunological attack mounted by a graft against the host because of HISTOINCOMPATIBILITY when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.	HLA Sensitization,Human Leukocyte Antigen Sensitization,Sensitization, HLA
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013163	Splenomegaly	Enlargement of the spleen.	Enlarged Spleen,Spleen, Enlarged