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The administration of gamma-butyrolactone (GBL) (750 mg . kg-1 i.p.) and baclofen (20 mg . kg-1 i.p.) to rats caused a transient increase followed by a long-lasting decrease in striatal dopamine (DA) synthesis, as measured by DOPA accumulation after decarboxylase inhibition. DA synthesis was reduced to 40-50% of the control value for 2-12 h following either treatment. The GBL- and baclofen-induced inhibition of DN synthesis was reversed by haloperidol (2-5 mg . kg-1 i.p.) and by a second dose of baclofen or GBL. The subcutaneous dose of 15 mg . kg-1 of apomorphine, insufficient to decrease DA synthesis in control rats, produced a further decrease in DA synthesis in animals pretreated with baclofen. These results suggest that the delayed DA synthesis inhibition following GBL or baclofen treatment was due to stimulation of supersensitive DA autoreceptors.
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
October 1972,
Biochemical pharmacology,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
February 1991,
Naunyn-Schmiedeberg's archives of pharmacology,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
April 2001,
Pharmacological research,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
February 1983,
Biochemical pharmacology,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
January 1991,
Journal of neural transmission. General section,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
January 1990,
Annals of the New York Academy of Sciences,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
June 1991,
Biochemical pharmacology,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
August 1981,
Life sciences,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
September 1983,
Biological psychiatry,
A Argiolas, and
F Fadda, and
M R Melis, and
M Marcou, and
M L Porceddu, and
G L Gessa
July 1993,
Journal of neurochemistry,
