Biomaterial Database

State-dependent learning in children receiving methylphenidate. 1982

V T Shea

Methylphenidate state-dependent learning was investigated using a paired-associate learning task of 16 pairs of pictures. Subjects were 15 children for whom methylphenidate was currently being prescribed. Each child was seen for two learning sessions and two testing sessions. Learning took place under placebo and under the child's regular dosage of methylphenidate. During retention testing all combinations of learning drug-state and testing drug-state were observed for each child. Data were analyzed using contrast variables which took into account the repeated-measures nature of the design. The results indicated that there was a trend in the direction of state-dependence in the whole sample. Significant symmetrical state-dependent effects were obtained in those subjects whose original learning was facilitated by methylphenidate.

UI	MeSH Term	Description	Entries
D008774	Methylphenidate	A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.	Centedrin,Concerta,Daytrana,Equasym,Metadate,Methylin,Methylphenidate Hydrochloride,Phenidylate,Ritalin,Ritalin-SR,Ritaline,Tsentedrin,Hydrochloride, Methylphenidate,Ritalin SR
D010153	Paired-Associate Learning	Learning in which the subject must respond with one word or syllable when presented with another word or syllable.	Learning, Paired-Associate,Learnings, Paired-Associate,Paired Associate Learning,Paired-Associate Learnings
D010364	Pattern Recognition, Visual	Mental process to visually perceive a critical number of facts (the pattern), such as characters, shapes, displays, or designs.	Recognition, Visual Pattern,Visual Pattern Recognition
D011939	Mental Recall	The process whereby a representation of past experience is elicited.	Recall, Mental
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D001289	Attention Deficit Disorder with Hyperactivity	A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)	ADHD,Attention Deficit Disorder,Attention Deficit Hyperactivity Disorder,Brain Dysfunction, Minimal,Hyperkinetic Syndrome,Minimal Brain Dysfunction,ADDH,Attention Deficit Disorders with Hyperactivity,Attention Deficit Hyperactivity Disorders,Attention Deficit-Hyperactivity Disorder,Attention Deficit Disorders,Attention Deficit-Hyperactivity Disorders,Deficit Disorder, Attention,Deficit Disorders, Attention,Deficit-Hyperactivity Disorder, Attention,Deficit-Hyperactivity Disorders, Attention,Disorder, Attention Deficit,Disorder, Attention Deficit-Hyperactivity,Disorders, Attention Deficit,Disorders, Attention Deficit-Hyperactivity,Dysfunction, Minimal Brain,Syndromes, Hyperkinetic