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This study was undertaken to investigate influences of a new vasodilator, YC-93, a derivative of 1,4-dihydropyridine, on cerebral circulation and cerebrovascular CO2 reactivity. Cerebrocortical PO2, cerebrocortical PCO2, cerebrocortical blood flow and arterial blood pressure were continuously recorded by means of a PO2 electrode, a PCO2 electrode and a plate-type crossed thermocouple flowmeter placed on an exposed pial surface of the cat brain. The changes in each parameter induced by YC-93 were compared with those induced by papaverine hydrochloride. The effects of 5% CO2 inhalation were compared before and after the intravenous injection of YC-93. YC-93 (0.01 mg/kg) showed a more marked and longer-lasting hypotensive effect that papaverine (1 mg/kg) and yet produced a significant increase in cerebrocortical PO2. After the administration of YC-93, the degree of the increase in cerebrocortical PO2 during 5% CO2 inhalation was reduced significantly in comparison with that before the administration. The above data indicates that YC-93 has a vasodilating effect on cerebral blood vessels and that the drug causes a decrease in cerebrovascular CO2 reactivity.
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
April 1975,
Surgical neurology,
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
June 1977,
International journal of clinical pharmacology and biopharmacy,
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
January 1980,
Clinical and experimental pharmacology & physiology,
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
January 1979,
International journal of clinical pharmacology and biopharmacy,
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
August 1982,
Japanese journal of pharmacology,
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
October 1981,
Japanese journal of pharmacology,
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
July 1975,
Journal of the neurological sciences,
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
June 1977,
Clinical science and molecular medicine,
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
December 1969,
Hospital (Rio de Janeiro, Brazil),
M Oishi, and
T Niimi, and
S Takagi, and
T Takeoka, and
T Seki, and
M Toyoda, and
F Gotoh
January 1979,
Therapia Hungarica (English edition),
