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Rolling mouse Nagoya (RMN), an ataxia mutant mouse, is adequate to checking up the efficacy of drugs on the ataxic movement disorders. The effects of some drugs on the ataxia of RMN were investigated by open field study. The drugs administered to RMN were as follows: TRH, FLA-63, DL-threo-DOPS, phenoxybenzamine and propranolol. Ataxic gait of RMN were remarkably improved by TRH, but remained unchanged by other drugs. The pretreatments with FLA-63, DOPS and phenoxybenzamine were not influenced to the antiataxic effects of TRH, while the pretreatment with propranolol increased the antiataxic effect of TRH in RMN. These results suggest that mechanism of the improvement of ataxic gait by TRH may not be sufficiently explained through only changing norepinephrine metabolism.
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
September 2020,
European journal of pharmacology,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
October 1992,
Journal of the neurological sciences,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
April 1988,
Neuroscience research,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
June 1986,
Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
December 2005,
Biological & pharmaceutical bulletin,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
June 1981,
Brain research,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
January 1981,
Rinsho shinkeigaku = Clinical neurology,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
January 1986,
Developmental psychobiology,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
April 1996,
Brain research,
K Matsui, and
E Toyoshima, and
U Mano, and
K Ando
May 2002,
Neuroscience letters,
