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The plasma concentrations of pyridostigmine were measured in eight patients during the antagonism of non-depolarizing neuromuscular blockade. After the injection i.v. of pyridostigmine bromide 14.6 mg/70 kg, the concentration of the drug rapidly decreased between 2 and 7 min, and then declined more slowly. After 2 h, significant amounts of pyridostigmine were still present in the plasma of all subjects. In the eight patients studied, the initial half-life was 1.0 +/- 0.3 min and the terminal half-life was 46.4 +/- 6.5 min (mean +/- SEM). Total body clearance of pyridostigmine was 8.7 +/- 1.5 ml min-1 kg-1, and the total apparent volume of distribution was 536 +/- 80 ml kg-1. Possible explanations for the differences between these results and previous studies are considered.
N E Williams, and
T N Calvey, and
K Chan
December 1981,
British journal of anaesthesia,
N E Williams, and
T N Calvey, and
K Chan
July 1982,
British journal of anaesthesia,
N E Williams, and
T N Calvey, and
K Chan
November 1977,
British journal of anaesthesia,
N E Williams, and
T N Calvey, and
K Chan
October 1984,
Der Anaesthesist,
N E Williams, and
T N Calvey, and
K Chan
May 1973,
Anesthesiology,
N E Williams, and
T N Calvey, and
K Chan
May 1979,
The Journal of pharmacy and pharmacology,
N E Williams, and
T N Calvey, and
K Chan
June 1991,
Anesthesiology,
N E Williams, and
T N Calvey, and
K Chan
September 1996,
British journal of anaesthesia,
N E Williams, and
T N Calvey, and
K Chan
July 1963,
Minerva anestesiologica,
N E Williams, and
T N Calvey, and
K Chan
January 1980,
Anesthesia and analgesia,
