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The effects of administration of metoprolol and propranolol on lidocaine elimination were studied in six healthy young men who did not smoke. Each received three single intravenous doses of lidocaine (2.5 to 3.0 mg/kg injected over 10 min): one alone, one after 1 day pretreatment with propranolol (40 mg orally every 6 hr), and one after 1 day pretreatment with metoprolol (50 mg orally every 6 hr). Lidocaine clearance was 0.88 +/- 0.28 l X hr-1 X kg-1 before beta blockade, 0.61 +/- 0.20 l X hr-1 X kg-1 during metoprolol dosing, and 0.47 +/- 0.16 l X hr-1 X kg-1 during propranolol dosing. There was no correlation between the change in lidocaine elimination and the steady-state concentrations of metoprolol or propranolol, nor between the change in lidocaine clearance and the change in resting heart rate produced by either beta blocker. Metoprolol and propranolol reduce lidocaine elimination significantly.
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
October 1980,
Clinical pharmacology and therapeutics,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
September 1979,
International journal of clinical pharmacology and biopharmacy,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
May 1987,
Journal of cardiovascular pharmacology,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
May 1980,
British heart journal,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
December 1978,
British medical journal,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
April 1977,
British medical journal,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
March 1990,
Biological psychiatry,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
February 1981,
The Journal of surgical research,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
January 1981,
Journal of clinical pharmacology,
K A Conrad, and
J M Byers, and
P R Finley, and
L Burnham
October 1980,
European journal of clinical pharmacology,
