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Fluorescence of hematoporphyrin derivative (HPD) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety of species, selective fluorescence of atheromatous plaques of the aorta was seen in each animal (rabbits and Patas monkey) exhibiting such lesions. No fluorescence could be demonstrated in aortic segments free of atheromatous involvement. Since the efficacy of photodynamic destruction of malignant tumors with HPD has been demonstrated in clinical studies, the observations of the present study may have therapeutic implications in atheromatosis.
J R Spears, and
J Serur, and
D Shropshire, and
S Paulin
January 1977,
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J R Spears, and
J Serur, and
D Shropshire, and
S Paulin
January 1988,
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J R Spears, and
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August 1997,
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J R Spears, and
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S Paulin
June 1965,
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J R Spears, and
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June 1968,
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J R Spears, and
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J R Spears, and
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S Paulin
January 1989,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
J R Spears, and
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January 1988,
Atherosclerosis,
J R Spears, and
J Serur, and
D Shropshire, and
S Paulin
February 1985,
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J R Spears, and
J Serur, and
D Shropshire, and
S Paulin
January 1986,
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