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This paper explores in patients with dialysis osteodystrophy the relationship between clinical features and histological, radiological, and biochemical findings. Eighty-five patients treated by hemodialysis for more than 6 months were studied. The following conclusions were drawn: 1) Bone pain in patients on regular hemodialysis is usually a symptom of developing osteomalacia but not of hyperparathyroidism or osteoporosis. 2) Many patients with histological osteomalacia and radiological features of osteomalacia, such as fractures or Looser zones, have no symptoms. 3)In dialysis patients, biochemical and radiological abnormalities are not a reliable means of predicting the presence of osteomalacia, but a raised serum alkaline phosphatase is a good indicator of the presence of osteitis fibrosa. For early detection of osteomalacia, bone biopsy in necessary. 4)A number of our dialysis patients develop an unusual form of osteomalacia characterized by absent or minimal histological osteitis fibrosa, a normal serum alkaline phosphatase, and a high incidence of myopathy and fractures.
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
January 1998,
Sao Paulo medical journal = Revista paulista de medicina,
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
November 2007,
World journal of surgical oncology,
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
June 2000,
Radiology,
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
June 2003,
American journal of obstetrics and gynecology,
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
June 2001,
American journal of obstetrics and gynecology,
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
December 2014,
Journal of endodontics,
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
April 2002,
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine,
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
December 1963,
Archives of ophthalmology (Chicago, Ill. : 1960),
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
November 1971,
Pediatrics,
F Alvarez-Ude, and
T G Feest, and
M K Ward, and
A M Pierides, and
H A Ellis, and
M Peart, and
W Simpson, and
D Weightman, and
D N Kerr
April 2014,
Journal of neuropathology and experimental neurology,
