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Diabetes of moderate severity was induced with streptozotocin in growth hormone (and therefore somatomedin)-deficient rats. Somatomedin inhibitors were identified in the serum and liver perfusate of these animals, as shown by the ability of samples to blunt basal cartilage sulfation and cartilage stimulation by added normal serum. The data suggest that the induction of somatomedin inhibitors is under the influence of insulin and nutrition rather than growth hormone, indicating that their regulation may differ from that of growth-promoting somatomedins. With this model, it is possible to obtain preparations that are relatively free of somatomedins in which to study the properties of somatomedin inhibitors.
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
June 1976,
Diabetes,
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
November 1982,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
September 1977,
Diabetes,
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
December 1982,
The Journal of clinical endocrinology and metabolism,
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
August 1986,
Diabetes,
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
January 1985,
The International journal of biochemistry,
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
August 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
January 1974,
Advances in metabolic disorders,
R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
May 1979,
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R Vassilopoulou-Sellin, and
C O Oyedeji, and
N A Samaan
April 1996,
Journal of the Egyptian Society of Parasitology,
