-transparent.png){kind=logo}
Synthetic gastrin releasing peptide (GRP) injected intraventricularly (1 microgram/rat), but not intravenously, suppressed rat prolactin (PRL) release induced by a Met-enkephalin analog, FK33-824 (10 micrograms/100 g body wt., iv). GRP also blunted PRL release induced by a dopamine antagonist, domperidone (1 microgram/100 g body wt., iv). In contrast, GRP did not suppress elevated plasma PRL levels sustained by a large dose of domperidone (10 micrograms/100 g body wt., iv). GRP (10(-5) M) had no effect on PRL release from superfused pituitary cells in vitro. These results suggest that GRP inhibits PRL secretion in the rat by acting through the brain to stimulate the dopaminergic mechanism.
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
October 1997,
Journal of gastroenterology,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
January 1995,
Life sciences,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
March 1984,
Regulatory peptides,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
April 1987,
Gastroenterologia Japonica,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
April 1992,
FEBS letters,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
December 2020,
Cells,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
January 1989,
Journal of chemical neuroanatomy,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
April 2004,
Cancer biotherapy & radiopharmaceuticals,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
January 1994,
Regulatory peptides,
N Matsushita, and
Y Kato, and
H Katakami, and
A Shimatsu, and
N Yanaihara, and
H Imura
February 1992,
Neuropeptides,
