Biomaterial Database

[Activity of lysosomal acid phosphatase in leukocytes of rats chronically intoxicated with benzene vapors]. 1978

P Moszczyński, and A Starek

In rats chronically exposed to benzene vapours of 1200 mg/m3 concentration, 6 hr daily, 6 days a week, during 12 weeks, acid phosphatase activity (AcP) was evaluated in neutrophils and lymphocytes of peripheral blood. One found an increase in AcP activity in neutrophils, correlating with duration of exposure, lymphocytopenia, correlating with duration of exposure, and increase in AcP--positive lymphocytes percentage, mainly with cytoplasmic and lysosomocytoplasmic localization of enzyme. Besides distant effects of chronic benzene intoxication were evaluated, 5 months after the exposure had been intermitted. Normal AcP activity in neutrophils, lymphocytopenia, and increase in AcP--positive lymphocytes percentage were found with cytoplasmic and lysosomo-cytoplasmic localization of enzyme. The authors suggest a possibility of using the changes observed in lymphocytes, on a subcellular level, to evaluate distant effects of occupational exposure to benzene.

UI	MeSH Term	Description	Entries
D007962	Leukocytes	White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).	Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008231	Lymphopenia	Reduction in the number of lymphocytes.	Lymphocytopenia,Lymphocytopenias,Lymphopenias
D008247	Lysosomes	A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured or undergoes MEMBRANE FUSION. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed).	Autolysosome,Autolysosomes,Lysosome
D008297	Male		Males
D000135	Acid Phosphatase	An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.	Acid beta-Glycerophosphatase,Acid beta Glycerophosphatase
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001554	Benzene	Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.	Benzol,Benzole,Cyclohexatriene
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus