-transparent.png){kind=logo}
Regional cerebral glucose utilization (rCMRGlc) was measured in awake unstressed rats by use of [2-14C]glucose autoradiography. Rats prepared by chronic catheterization of the jugular and epigastric veins were placed in specially designed chambers after surgery. The catheters were passed through the top of the chambers. Seven days after surgery, plasma glucose was normal (7.5 mM), plasma ketone bodies were low (0.13 mM), and body weight was maintained. Plasma epinephrine was 31 pg/ml; approximately 3% of the level for stressed (immobilized) rats. Injections and blood sampling through the catheters did not produce changes in heart rate, blood pressure, plasma catecholamines, or blood metabolites. Visual observations did not reveal any signs that the rats were aware of the [2-14C]glucose injections and the subsequent blood sampling. The rCMRGlc in stressed rats was significantly greater than in unstressed rats. This method provides a model for physiological studies in unstressed unanesthetized rats.
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
July 1990,
Neuroscience letters,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
January 1987,
Psychopharmacology,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
April 1990,
Critical care medicine,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
October 1987,
The American journal of physiology,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
March 1990,
Brain research,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
January 1993,
Basic research in cardiology,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
July 1982,
Journal of neurochemistry,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
October 1991,
The American journal of physiology,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
July 1988,
Brain research,
R M Bryan, and
R A Hawkins, and
A M Mans, and
D W Davis, and
R B Page
October 1995,
Journal of neurosurgical anesthesiology,
