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Surface structures of the peritoneal macrophages of BALB/c mice treated intramuscularly with various doses of egg lysozyme (0.05 to 50 mg/kg) were studied with scanning electron microscopy. It was shown that the effect of lysozyme on the macrophages significantly depended on the dose of the preparation and the frequency of its use. When used in the subtherapeutic (0.5 mg/kg) and therapeutic (5 mg/kg) single doses, lysozyme promoted detection of heterogeneity of the macrophage population, marked activation of their surface membranes and intensification of intercellular cooperation. The highest level of the lysozyme activating effect on the minor macrophages and lymphocytes was observed after administration of the preparation in a single dose of 5 mg/kg or in a dose of 0.5 mg/kg repeatedly (daily for 7 days). When used in a dose of 5 mg/kg repeatedly or especially in a single dose of 50 mg/kg lysozyme induced smoothing of the surface of the macrophages and lymphocytes. The problems of indirect, direct and immune activation of the macrophages with lysozyme are discussed.
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
November 1984,
Antibiotiki,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
June 2018,
Cytotechnology,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
November 1978,
Toxicology,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
January 1990,
Histochemistry,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
January 1989,
FEBS letters,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
January 1976,
Laboratory investigation; a journal of technical methods and pathology,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
November 1975,
Israel journal of medical sciences,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
November 1980,
Biochemical pharmacology,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
September 1982,
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
E G Shcherbakova, and
E L Soboleva, and
G A Rastunova
May 1976,
The Journal of cell biology,
