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The rate of sulfadimethoxine excretion from blood in patients with mechanical jaundice and cholangitis is the same as that in healthy persons. The renal excretion of the drug in such patients does not undergo any significant changes either. However, excretion of sulfadimethoxine with bile is impaired and the level of suppression of renal excretory function is proportional to the jaundice period. After decompression of the bile ducts renal excretory function in patients with mechanical jaundice is recovered.
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