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A rapid immunochemical method (Isomune-LD) for the determination of lactate dehydrogenase isoenzyme 1 (LD1) activity in serum was investigated, and the sensitivity and specificity of the assay were determined for the diagnosis of a myocardial infarction (MI). Multiple serum samples were obtained (on admission and at 12, 24, and 48 hours) from 85 patients (30 with proven MI and 55 without MI). The sensitivity of LD1 on admission and at 12, 24, and 48 hours was 43%, 84%, 96%, and 100%, respectively, and the specificity at these same time intervals was 95%, 100%, 97%, and 97%, respectively. Thus, the determination of LD1 by this rapid immunochemical method appears to allow a rapid laboratory evaluation of MI with a high degree of sensitivity and specificity.
M T McCoy, and
J J Aguanno, and
S E Ritzmann
January 1984,
Clinical chemistry,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
August 1984,
Clinical chemistry,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
April 1973,
Vrachebnoe delo,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
January 1984,
Journal of applied biochemistry,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
November 1981,
Ugeskrift for laeger,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
May 1982,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
July 1990,
Clinical chemistry,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
October 1990,
Clinical chemistry,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
January 1994,
Annals of clinical and laboratory science,
M T McCoy, and
J J Aguanno, and
S E Ritzmann
October 1982,
Clinical chemistry,
