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Oxazepam and diazepam were compared in healthy elderly volunteers. Absorption of diazepam was faster than oxazepam and onset of clinical effects were more profound. Diazepam accumulation was extensive, washout was slow and active compounds were present two weeks after the last dose. Oxazepam accumulation was significantly less and elimination significantly faster than diazepam. There was no difference between oxazepam and diazepam in sedation or fatigue during the drug treatment, but sedative effects persisted for two weeks after diazepam therapy was discontinued. Sedation rapidly returned to baseline in the oxazepam group. Thus, the differing pharmacokinetic profiles of diazepam and oxazepam have clinical consequences during multiple dosage in the elderly.
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
April 1977,
Journal of pharmaceutical sciences,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
April 1984,
Rational drug therapy,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
December 1988,
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
December 1989,
JAMA,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
July 1986,
Ugeskrift for laeger,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
January 1977,
Acta pharmacologica et toxicologica,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
May 1970,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
December 1967,
Arzneimittel-Forschung,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
July 1970,
Actas luso-espanolas de neurologia y psiquiatria,
C Salzman, and
R I Shader, and
D J Greenblatt, and
J S Harmatz
January 1984,
Current medical research and opinion,
