BIOMAT Database Logo BIOMAT Database Logo

[Preservation of an isolated kidney in normothermic conditions by perfluorotributylamine emulsion perfusion]. 1983

N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako

Perfluorotributylamine emulsion (PFE) was used to preserve an isolated dog kidney under normothermal conditions with the aid of perfusion. The latter was carried out for 4 hours with the use of a pulse pump. The protein-saline solution (PSS) - 5% donor's albumin in Hanks solution, was used for reference purposes. During PFE perfusion, oxygen consumption by the kidney was noticed to be increased at the expense of a rise in the arterio-venous difference. Glucose concentration in the perfusate was unchanged during PFE perfusion, while that in PSS declined. Lactate dehydrogenase activity in PFE was noticeably lower than in PSS. During PFE perfusion, the concentration capacity of the kidney was 3.5 times higher as regards creatinine and 7.5 higher as regards potassium. It has been demonstrated that the 4-hour normothermal renal perfusion with 20 v% PFE enables preservation of the renal function.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D009926 Organ Preservation The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism). Organ Preservations,Preservation, Organ,Preservations, Organ
D010100 Oxygen An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. Dioxygen,Oxygen-16,Oxygen 16
D010101 Oxygen Consumption The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346) Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D010477 Perfusion Treatment process involving the injection of fluid into an organ or tissue. Perfusions
D003470 Culture Media Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. Media, Culture
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D004655 Emulsions Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES. Emulsion
D005466 Fluorocarbons Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions, and fluorocarbon blood substitutes. Perfluorinated and related polyfluorinated chemicals are referred to as PFAS and are defined as chemicals with at least two adjacent carbon atoms, where one carbon is fully fluorinated and the other is at least partially fluorinated. Fluorocarbon,Fluorocarbon Emulsion,Fluorocarbon Emulsions,Fluorotelomer Phosphate Esters,N-Alkyl Perfluoroalkyl Sulfonamido Carboxylates,PFAS Per- and Polyfluoroalkyl Substances,PFC Perfluorinated Chemicals,PFECAs Perfluoropolyether Carboxylic Acids,Per- and Polyfluoroalkyl Substances,Perfluoroalkane Sulfonamides,Perfluoroalkyl Carboxylates,Perfluoroalkyl Ether Carboxylates,Perfluoroalkyl Polyether Carboxylates,Perfluorocarbon,Perfluorocarbons,Perfluoropolyether Carboxylic Acids,Polyfluorocarbons,Fluorinated Telomer Alcohols,Fluoro-Telomer Alcohols,Polyfluorinated Telomer Alcohols,Telomer Fluorocarbons,Acids, Perfluoropolyether Carboxylic,Alcohols, Fluorinated Telomer,Alcohols, Fluoro-Telomer,Alcohols, Polyfluorinated Telomer,Carboxylates, Perfluoroalkyl,Carboxylates, Perfluoroalkyl Ether,Carboxylates, Perfluoroalkyl Polyether,Carboxylic Acids, Perfluoropolyether,Chemicals, PFC Perfluorinated,Emulsion, Fluorocarbon,Emulsions, Fluorocarbon,Esters, Fluorotelomer Phosphate,Ether Carboxylates, Perfluoroalkyl,Fluoro Telomer Alcohols,Fluorocarbons, Telomer,N Alkyl Perfluoroalkyl Sulfonamido Carboxylates,PFAS Per and Polyfluoroalkyl Substances,Per and Polyfluoroalkyl Substances,Perfluorinated Chemicals, PFC,Phosphate Esters, Fluorotelomer,Polyether Carboxylates, Perfluoroalkyl,Sulfonamides, Perfluoroalkane,Telomer Alcohols, Fluorinated,Telomer Alcohols, Polyfluorinated
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose

Related Publications

N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
Isolated normothermic perfusion of kidney using extracorporeal circulation.
May 1969, The Indian journal of medical research,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
Normothermic kidney preservation.
April 2011, Current opinion in organ transplantation,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
The assessment of renal preservation by normothermic bloodless perfusion.
April 1976, Cryobiology,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
Two-day preservation of the lungs by normothermic perfusion.
January 1994, Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
Normothermic preservation of isolated organs.
July 1981, Journal of biomedical engineering,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
[Preservation of the vital capacity of isolated kidneys and livers of animals under conditions of extracorporeal normothermic perfusion].
July 1970, Vestnik khirurgii imeni I. I. Grekova,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation.
July 2015, Journal of visualized experiments : JoVE,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
Porcine Normothermic Isolated Liver Perfusion.
June 2023, Journal of visualized experiments : JoVE,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
Experimental renal preservation by normothermic resuscitation perfusion with autologous blood.
January 2008, The British journal of surgery,
N N Kontuganov, and N E Shcherbakova, and N I Afonin, and V I Kirpatovskiĭ, and A A Lubiako
Normothermic kidney perfusion: An overview of protocols and strategies.
April 2021, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Copied contents to your clipboard!