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Scanning electron microscopy was used to examine the appearances of the colonic mucus layer of rats during chemical carcinogenesis with dimethylhydrazine. The normal colonic mucus layer had a dense homogeneous appearance and provided a complete cover for the mucosal epithelium. At high magnifications tiny fenestrations could be seen in this mucus layer. During carcinogenesis these fenestrations enlarged, increased in number, and coalesced, causing focal defects in the mucus layer, which eventually broke into strands and clumps of mucus. The findings indicate that the colonic mucus layer develops progressive abnormalities during carcinogenesis which result in breakdown of its integrity and exposure of the mucosal epithelium to colonic contents.
O J Traynor, and
N L Costa, and
C B Wood
October 1979,
Journal (Canadian Dental Association),
O J Traynor, and
N L Costa, and
C B Wood
January 1983,
Folia histochemica et cytochemica,
O J Traynor, and
N L Costa, and
C B Wood
October 1975,
Obstetrics and gynecology,
O J Traynor, and
N L Costa, and
C B Wood
January 1987,
Ultrastructural pathology,
O J Traynor, and
N L Costa, and
C B Wood
October 1974,
Journal of reproduction and fertility,
O J Traynor, and
N L Costa, and
C B Wood
October 1973,
Fertility and sterility,
O J Traynor, and
N L Costa, and
C B Wood
January 1976,
Journal de gynecologie, obstetrique et biologie de la reproduction,
O J Traynor, and
N L Costa, and
C B Wood
January 1986,
Archivio italiano di anatomia e di embriologia. Italian journal of anatomy and embryology,
O J Traynor, and
N L Costa, and
C B Wood
October 2007,
ACS nano,
O J Traynor, and
N L Costa, and
C B Wood
May 2004,
Calcified tissue international,
