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The influence of atrial systole on the left ventricular function curve (stroke volume vs end-diastolic pressure or end-diastolic diameter) and on the left ventricular end-diastolic pressure diameter relation was studied in nine anesthetized, open-chest dogs whose atrioventricular (AV) node had been completely blocked. Measurements were made during volume loading with the pericardium closed and opened and during alternate AV sequential pacing (to permit atrial contribution to ventricular filling) and AV simultaneous pacing (to prevent atrial contribution). When the pericardium was closed, withdrawal of the atrial contribution shifted the stroke-volume end-diastolic pressure relation downward, but did not shift the stroke volume-end-diastolic diameter relation, i.e., it reduced stroke volume for a given end-diastolic pressure according to a reduction in end-diastolic volume. The downward shift of the stroke volume-end-diastolic pressure relation was caused by an upward shift of the end-diastolic pressure-diameter relation, which, for a given end-diastolic pressure, resulted in a smaller end-diastolic diameter and, thus, in a smaller stroke volume. The reason for the upward shift in the end-diastolic pressure-diameter relation was that the atrium remained full and thus increased pericardial pressure by increasing pericardial volume. Opening the pericardium shifted the end-diastolic pressure-diameter relation downward and to the right, shifted the stroke volume-end-diastolic diameter relation upward and abolished the effect of withdrawal of the atrial contribution on these curves. We conclude that in the presence of an intact pericardium, atrial systole shifts the stroke volume-end-diastolic pressure relation because it shifts the end-diastolic pressure-diameter relation and it improves left ventricular performance by increasing preload.
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
July 2009,
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
September 1981,
The Journal of thoracic and cardiovascular surgery,
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
April 1979,
Circulation,
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
July 1966,
The American journal of physiology,
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
November 1990,
Circulation,
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
July 2000,
Arquivos brasileiros de cardiologia,
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
September 1987,
Japanese circulation journal,
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
December 1995,
Cardiologia (Rome, Italy),
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
June 1989,
Kokyu to junkan. Respiration & circulation,
T Linderer, and
K Chatterjee, and
W W Parmley, and
R E Sievers, and
S A Glantz, and
J V Tyberg
January 1974,
Archives internationales de physiologie et de biochimie,
