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Studies were undertaken to evaluate the effects of cysteamine on serum and anterior pituitary concentrations of prolactin in hyperprolactinemic female rats. Serum prolactin was elevated in young (4 to 5 months old) rats by implantation of 17 beta-estradiol while 26- to 28-month-old rats were in constant estrus and exhibited an age-related hyperprolactinemia. At 4 h after treatment with cysteamine (90 mg/kg body wt) serum and anterior pituitary prolactin concentrations were reduced in young animals by 98 and 85%, respectively. In old constant-estrous rats, cysteamine reduced serum prolactin by 92% and anterior pituitary prolactin by 82%. In young pseudopregnant rats, cysteamine induced a prompt resumption of estrous cycles. These studies indicate that cysteamine is an effective depletor of serum and pituitary prolactin in hyperprolactinemic rats.
J W Simpkins, and
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W J Millard, and
S M Sagar, and
J B Martin
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J W Simpkins, and
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J B Martin
January 1991,
Life sciences,
J W Simpkins, and
K S Estes, and
W J Millard, and
S M Sagar, and
J B Martin
March 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J W Simpkins, and
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W J Millard, and
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May 2000,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
J W Simpkins, and
K S Estes, and
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July 1976,
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J W Simpkins, and
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J B Martin
January 1996,
Life sciences,
J W Simpkins, and
K S Estes, and
W J Millard, and
S M Sagar, and
J B Martin
October 1984,
Endocrinology,
J W Simpkins, and
K S Estes, and
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J B Martin
March 1996,
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J W Simpkins, and
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S M Sagar, and
J B Martin
August 1987,
Endocrinology,
J W Simpkins, and
K S Estes, and
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J B Martin
October 1987,
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