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The effect on respiratory burst of murine splenic cells after in vitro exposure to synthetic muramyl dipeptide (MDP) and 6-O-acyl and quinonyl derivatives was studied at an early phase of interaction by luminol-dependent chemiluminescence (CL) in response to stimulation by zymosan. The MDP molecule enhanced CL, but the degree of CL response varied with the kinds of fatty acids introduced in the chemical structure of synthetic glycopeptide analogs. A 6-O-acyl derivative possessing an alpha-branched fatty acid chain, B30-MDP, stimulated maximum levels of CL activity. High CL responses were obtained with L8-MDP having a short chain of linear fatty acids and with QS-10-MDP-66 containing a ubiquinone compound. CL was also stimulated by MDP and its analogs in the spleen cells of nude mice lacking mature T lymphocytes, but the extent of stimulation was decreased compared with that of normal spleen cells.
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
December 1978,
Pathologie-biologie,
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
January 1985,
Microbiology and immunology,
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
January 1978,
Antibiotics and chemotherapy,
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
February 1978,
Biochemical and biophysical research communications,
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
November 1989,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
August 1989,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
February 1978,
Journal of immunology (Baltimore, Md. : 1950),
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
December 1982,
Infection and immunity,
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
March 1983,
Infection and immunity,
K N Masihi, and
I Azuma, and
W Brehmer, and
W Lange
May 1981,
Infection and immunity,
