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Dihydroxydibutylether (DHBE, 900 mg/day, in divided doses) was given to 13 patients with radiolucent gallstones. Bile lipid composition and bile saturation were studied before treatment and after 1 and 2 months of therapy. Bile was collected by duodenal intubation (after cerulein-induced gallbladder contraction) in each patient, and biliary lipids were estimated with standard laboratory techniques. The results of this study showed that DHBE treatment was associated with a significant (p less than 0.01) reduction of bile saturation with cholesterol (saturation index: 1.37 +/- 0.39 before treatment, 1.14 +/- 0.35 after 1 month, and 1.08 +/- 0.29 after 2 months). The possible mechanism of this effect and the clinical relevance are discussed.
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
June 1981,
International journal of clinical pharmacology, therapy, and toxicology,
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
January 1983,
Digestion,
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
December 1978,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
January 1980,
Arzneimittel-Forschung,
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
July 2001,
Journal of gastroenterology and hepatology,
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
March 1979,
Hiroshima journal of medical sciences,
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
August 1974,
Lancet (London, England),
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
February 1983,
International journal of clinical pharmacology, therapy, and toxicology,
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
April 1978,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M Ponz de Leon, and
P Loria, and
R Iori, and
I Piccagli, and
N Carulli, and
A Belvisi, and
M Matergi
December 1978,
Gastroenterology,
