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Male Fischer-344 rats were exposed to target concentrations of 0, 50, 150 or 450 ppm ethylene oxide (EO) for 6 h/day for 1 or 3 days. Blood was removed by cardiac puncture and cultured in the presence of 5-bromodeoxyuridine for sister-chromatid exchange (SCE) and chromosome-breakage analyses. EO caused a concentration-dependent increase in SCE following both 1 and 3 days of exposure, and the effects appeared to be additive. No significant dose-dependent increase in chromosome breakage was observed, and reasons for this apparent discrepancy with other published data are discussed. These findings are consistent with the occurrence of elevated SCE frequencies in occupationally-exposed workers, and the results demonstrate for the first time that SCE can be detected in cultured lymphocytes of rodents following inhalation exposures.
A D Kligerman, and
G L Erexson, and
M E Phelps, and
J L Wilmer
January 1993,
Environmental and molecular mutagenesis,
A D Kligerman, and
G L Erexson, and
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J L Wilmer
October 1984,
Toxicology and applied pharmacology,
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G L Erexson, and
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J L Wilmer
November 1997,
Mutation research,
A D Kligerman, and
G L Erexson, and
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J L Wilmer
January 1982,
Environmental mutagenesis,
A D Kligerman, and
G L Erexson, and
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IARC scientific publications,
A D Kligerman, and
G L Erexson, and
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J L Wilmer
January 1983,
Annales de genetique,
A D Kligerman, and
G L Erexson, and
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January 1993,
IARC scientific publications,
A D Kligerman, and
G L Erexson, and
M E Phelps, and
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January 1984,
Journal of occupational medicine. : official publication of the Industrial Medical Association,
A D Kligerman, and
G L Erexson, and
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J L Wilmer
February 1999,
British journal of anaesthesia,
A D Kligerman, and
G L Erexson, and
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J L Wilmer
March 1983,
Science (New York, N.Y.),
