Biomaterial Database

Studies on liver toxicants: influence of bromobenzene on hepatic microsomal drug-metabolizing enzymes in the hamster. 1983

D G Mayer, and F E Beyhl

The effect of bromobenzene on hepatic microsomal drug-metabolizing enzymes was investigated in hamsters after oral applications of 1.5 and 3.0 g/kg body weight. After 1.5 g/kg a decrease of aminopyrine N-demethylase as well as an increase of hepatic hydroperoxide formation occurred. At 3.0 g/kg, most mixed-function oxidases were inhibited with the exception of ketamine N-demethylase, methylayapanine O-demethylase, and coumarin 7-hydroxylase. Hydroperoxide formation was increased but lipoperoxidation was reduced. Neither glucuronyltransferase I nor glucuronyltransferase II were affected by bromobenzene treatment.

UI	MeSH Term	Description	Entries
D008647	Mesocricetus	A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research.	Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D008862	Microsomes, Liver	Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.	Liver Microsomes,Liver Microsome,Microsome, Liver
D001969	Bromobenzenes	Derivatives of benzene in which one or more hydrogen atoms on the benzene ring are replaced by bromine atoms.
D005260	Female		Females
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D006899	Mixed Function Oxygenases	Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.	Hydroxylase,Hydroxylases,Mixed Function Oxidase,Mixed Function Oxygenase,Monooxygenase,Monooxygenases,Mixed Function Oxidases,Function Oxidase, Mixed,Function Oxygenase, Mixed,Oxidase, Mixed Function,Oxidases, Mixed Function,Oxygenase, Mixed Function,Oxygenases, Mixed Function
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia