Relationship between cure rate of human cancer and delivered dose in radiotherapy. 1983

Y Okumura, and T Norimura, and S Okajima

The cure rate of tumors was analysed by a model, and applied to human cancer. The cure rate increased linearly when plotted on a probit scale against dose in logarithm. The coefficient of variation, the ratio of one standard deviation to the dose of 50% cure, was taken as an indicator. The minimum value of the coefficient of variation was 5% obtained theoretically, and 10% clinically. This difference might be due to the variability existing in cancer of patients. The complications to the normal tissues, which was induced by the radiotherapy of cancer, were also analysed. The coefficient of variation for the complication showed the same tendency to that of the cure rate. The cures without complications were affected by the coefficients of variation for the cure rate and for the complication rate. The coefficient of variation for the cure rate is determined by the stochastic effect of cell killing and the error in dose estimation. When the physical error was 5%, its effect on the cure rate could be negligible. But when its error became more than 10%, a significant difference of the cure rate would be observed clinically in some tumors. The accuracy of the dose estimation was emphasized.

UI MeSH Term Description Entries
D008433 Mathematics The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Mathematic
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D011879 Radiotherapy Dosage The total amount of radiation absorbed by tissues as a result of radiotherapy. Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D004307 Dose-Response Relationship, Radiation The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation. Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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