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The effect of semistarvation on the toxicity and ototoxicity of tobramycin sulfate (TO) and gentamicin sulfate (GE) was investigated in guinea pigs by electrophysiological and histopathological methods. The presented data has shown that the toxicity and ototoxicity of aminoglycoside antibiotics is substantially increased when guinea pigs were semistarved. Our results should also warn researchers using semistarvation in their conditioning experiments which investigate the toxicity of different chemicals. Toxicity was greater in GE- than TO-treated animals, which caused the GE-treated animals to die during treatment or shortly after treatment. Thus, TO should be preferentially used because it has been shown to be less toxic and ototoxic in normal and altered nutritional conditions.
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
January 1986,
American journal of otolaryngology,
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
April 2003,
Drugs of today (Barcelona, Spain : 1998),
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
March 2001,
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology,
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
October 2007,
Current opinion in otolaryngology & head and neck surgery,
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
December 1983,
Lancet (London, England),
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
May 1978,
The Journal of antimicrobial chemotherapy,
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
February 1980,
American journal of otolaryngology,
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
April 2014,
Neuroscience,
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
January 1985,
ORL; journal for oto-rhino-laryngology and its related specialties,
J Prazma, and
H G Garrison, and
S K Williford, and
S D Ferguson, and
J Fischer, and
A Drake, and
L E Klingler
January 1988,
Zhonghua er bi yan hou ke za zhi,
