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A long-term, implantable, electrically actuated left ventricular assist system (THI/Gould LVAS) is being developed and characterized in vitro and in vivo for utilization in patients with end-stage heart disease. This system consists of five major components: a long-term, implantable blood pump (THI E-type ALVAD); an electrical-mechanical energy converter (Gould Model V); a control unit with batteries; a volume compensation system; and an external power supply and monitoring unit. Two of these components (blood pump and electrical-mechanical energy converter) have been integrated, and are undergoing chronic in vivo evaluations in calves. Thus far, 44 pneumatically and electrically actuated THI/Gould LVAS evaluations have been performed. This experience has resulted in greater than 6.5 years of actuation in vivo, with durations exceeding 1 year. System in vivo performance in terms of durability, mechanical reliability, hemodynamic effectiveness, and biocompatibility has been satisfactory. Demonstration of long-term (2-year) effectiveness in supporting the circulation is the ultimate goal.
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
July 1980,
American journal of surgery,
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
January 1983,
Transactions - American Society for Artificial Internal Organs,
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
January 1984,
Transactions - American Society for Artificial Internal Organs,
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
July 1984,
The Journal of thoracic and cardiovascular surgery,
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
January 1995,
ASAIO journal (American Society for Artificial Internal Organs : 1992),
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
January 1995,
ASAIO journal (American Society for Artificial Internal Organs : 1992),
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
January 1995,
ASAIO journal (American Society for Artificial Internal Organs : 1992),
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
January 1983,
Transactions - American Society for Artificial Internal Organs,
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
January 1981,
Transactions - American Society for Artificial Internal Organs,
J C Norman, and
M G McGee, and
J M Fuqua, and
S R Igo, and
S A Turner, and
R Sterling, and
C O Urrutia, and
O H Frazier, and
W C Clay, and
J A Chambers
January 1983,
Transactions - American Society for Artificial Internal Organs,
