-transparent.png){kind=logo}
In a 13-year-old German girl a GPI deficiency was found to be the cause of a chronic nonspherocytic hemolytic anemia with recurrent hemolytic crises. The hemolytic crises usually occurred after a feverish infection. Only once did the patient require blood transfusion during a crisis. Examination of the family indicated that the patient is doubly heterozygous for the deficiency. The investigation of the biochemical properties of the deficient enzyme revealed an altered electrophoretic migration, a pronounced thermolability, an increased affinity for G-6-P and slightly changed pH optima for both substrates. The described properties of the deficient GPI indicate that we are dealing with a new variant designated GPI-Kaiserlautern.
H Arnold, and
K Hasslinger, and
I Witt
September 1977,
Blut,
H Arnold, and
K Hasslinger, and
I Witt
April 1977,
Klinische Wochenschrift,
H Arnold, and
K Hasslinger, and
I Witt
February 1983,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
H Arnold, and
K Hasslinger, and
I Witt
January 1990,
Pediatriia,
H Arnold, and
K Hasslinger, and
I Witt
June 1973,
Blut,
H Arnold, and
K Hasslinger, and
I Witt
December 1997,
Blood cells, molecules & diseases,
H Arnold, and
K Hasslinger, and
I Witt
January 1974,
Pediatric research,
H Arnold, and
K Hasslinger, and
I Witt
June 1975,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
H Arnold, and
K Hasslinger, and
I Witt
June 1994,
Harefuah,
H Arnold, and
K Hasslinger, and
I Witt
July 1967,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
