Biomaterial Database

Bronchial response to inhaled histamine in asymptomatic young smokers. 1983

D W Cockcroft, and B A Berscheid, and K Y Murdock

Non-specific bronchial response to inhaled histamine was measured in 21 young (21.2 +/- 1.9 years) asymptomatic smokers (2.9 +/- 2.1 pack years) and in 21 age, sex, and height matched asymptomatic controls. Following a 2 min inhalation of histamine 8 mg/ml, the smokers showed smaller reduction in FEV1 (3.4 +/- 3.3% vs 7.0 +/- 6.2%, p less than 0.05) and in MMF (7.6 +/- 15.6% vs 21.1 +/- 17.3%, p less than 0.02) than did the non-smokers. The threshold concentration of histamine was defined as that concentration where FEV1 consistently was greater than 2 SD below the mean of that obtained from 5 to 7 prehistamine spirograms. A histamine threshold between 2 and 8 mg/ml was detectable in seven smokers, and a threshold between 1 and 8 mg/ml was seen in 14 non-smokers. Histamine threshold was not measurable (i.e. greater than 8 mg/ml) in 14 smokers and seven non-smokers (p less than 0.05). Thus, these young asymptomatic smokers of brief duration failed to show increased response to histamine; in fact, they appeared to respond less to histamine than did matched controls. This may be the result of selection (who chooses to smoke) or alternatively it may be due to an acquired loss of sensitivity (development of tolerance) to inhaled irritants.

UI	MeSH Term	Description	Entries
D008173	Lung Diseases, Obstructive	Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.	Obstructive Lung Diseases,Obstructive Pulmonary Diseases,Lung Disease, Obstructive,Obstructive Lung Disease,Obstructive Pulmonary Disease,Pulmonary Disease, Obstructive,Pulmonary Diseases, Obstructive
D008450	Maximal Midexpiratory Flow Rate	Measurement of rate of airflow over the middle half of a FORCED VITAL CAPACITY determination (from the 25 percent level to the 75 percent level). Common abbreviations are MMFR and FEF 25%-75%.	Forced Expiratory Flow 025-075 Percent,FEF 25-75 Percent,Flow Rate, Maximal Midexpiratory,MMFR,25-75 Percent, FEF,25-75 Percents, FEF,FEF 25 75 Percent,FEF 25-75 Percents,Forced Expiratory Flow 025 075 Percent,Percent, FEF 25-75,Percents, FEF 25-75
D001980	Bronchi	The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.	Primary Bronchi,Primary Bronchus,Secondary Bronchi,Secondary Bronchus,Tertiary Bronchi,Tertiary Bronchus,Bronchi, Primary,Bronchi, Secondary,Bronchi, Tertiary,Bronchus,Bronchus, Primary,Bronchus, Secondary,Bronchus, Tertiary
D005541	Forced Expiratory Volume	Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.	Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory
D006632	Histamine	An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.	Ceplene,Histamine Dihydrochloride,Histamine Hydrochloride,Peremin
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012907	Smoking	Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand.	Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits