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The effectiveness of fixed combination tablets of timolol 10 mg. hydrochlorothiazide 25 mg and amiloride 2.5 mg (Moducrin) once daily in the control of blood pressure has been assessed in fully ambulant hypertensives by the technique of continuous intra-arterial recording. Highly significant blood pressure reduction (p less than 0.001) was obtained consistently throughout the whole day, confirming the potency and usefulness of the preparation for those patients who need more than one drug to control their blood pressure. 2. Blood pressure responses to both isometric and dynamic forms of exercise were also significantly lowered by combination therapy. 3. The addition of a diuretic to a beta-adrenoceptor blocker appears to be an advantage if the aim of treatment in hypertension is 24 h blood pressure control.
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
December 1980,
Clinical pharmacology and therapeutics,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
October 1977,
European journal of clinical pharmacology,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
January 1987,
Annals of clinical research,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
April 1983,
Journal of clinical pharmacology,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
January 1982,
Current medical research and opinion,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
September 1981,
La Clinica terapeutica,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
January 1990,
Sovetskaia meditsina,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
May 1980,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
September 1983,
Tropical and geographical medicine,
R S Hornung, and
B A Gould, and
H Kieso, and
E B Raftery
January 1980,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
