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To establish whether there is any significant relationship between high-density lipoprotein cholesterol (HDLC) concentrations and biopsy-documented liver disease, 169 patients had needle biopsies, serum cholesterol, and HDLC evaluated. Twenty-four patients had serial cholesterol, HDLC, prothrombin, and aminotransferase levels and activities examined. In both men and women, HDLC decreased strikingly and significantly in acute alcoholic hepatitis and in acute viral hepatitis, compared to controls (p less than 0.001). Men and women with inactive alcoholic liver disease and chronic active hepatitis showed moderate decreased in HDLC (p less than 0.001). Patients with primary and metastatic hepatic neoplasms also had strikingly decreased HDLC (p less than 0.001). Serial testing showed an excellent direct correlation between HDLC and prothrombin activity, r values ranging from 0.71 to 0.98. Although alcohol intake is known to correlate positively with HDLC concentrations, our data shows that this association is not absolute, and in most cases is reversed once liver disease becomes apparent.
G C Kanel, and
G Radvan, and
R L Peters
September 2006,
Metabolism: clinical and experimental,
G C Kanel, and
G Radvan, and
R L Peters
September 1991,
BMJ (Clinical research ed.),
G C Kanel, and
G Radvan, and
R L Peters
July 1981,
Archives of neurology,
G C Kanel, and
G Radvan, and
R L Peters
November 2023,
Indian heart journal,
G C Kanel, and
G Radvan, and
R L Peters
January 2004,
Cardiology in review,
G C Kanel, and
G Radvan, and
R L Peters
August 2003,
Current opinion in lipidology,
G C Kanel, and
G Radvan, and
R L Peters
January 1979,
The Medical journal of Australia,
G C Kanel, and
G Radvan, and
R L Peters
October 1981,
The American journal of medicine,
G C Kanel, and
G Radvan, and
R L Peters
July 2023,
Zhonghua xin xue guan bing za zhi,
G C Kanel, and
G Radvan, and
R L Peters
May 1982,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
