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The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% inhibition of the uptake of 3H-tryptophan and 3H-choline were 33 and 16 muM, respectively. Kinetic analysis showed that inhibition of both compounds were consistent with a noncompetitive mechanism. The pretreatment of mice with doses of 10, 30 or 100 mg/kg delta9-THC had no effect on the subsequent in vitro synaptosomal uptake of either 3H-tryptophan or 3H-choline into forebrain synaptosomes.
K M Johnson, and
W L Dewey
September 1973,
Revue canadienne de biologie,
K M Johnson, and
W L Dewey
June 1974,
Research communications in chemical pathology and pharmacology,
K M Johnson, and
W L Dewey
February 1977,
Current therapeutic research, clinical and experimental,
K M Johnson, and
W L Dewey
June 1982,
Neuropharmacology,
K M Johnson, and
W L Dewey
November 1999,
Neurochemical research,
K M Johnson, and
W L Dewey
August 1977,
Biochemical pharmacology,
K M Johnson, and
W L Dewey
May 1975,
Biochemical pharmacology,
K M Johnson, and
W L Dewey
January 1976,
Proceedings of the Western Pharmacology Society,
K M Johnson, and
W L Dewey
September 2005,
Journal of analytical toxicology,
K M Johnson, and
W L Dewey
April 1974,
Biochemical pharmacology,
