Biomaterial Database

A geographic cluster of testicular seminomas. 1983

P S Feldman, and S S Howards, and C Harris, and C Harris

There have been many reports of space-time clusters of patients with Hodgkin's disease, childhood leukemia and Burkitt's lymphoma. We present a tight space cluster of 4 men with pathologically confirmed testicular seminomas. None of the men had any known reason to be at increased risk for testicular cancer. They all lived in the same immediate neighborhood for at least 7 years. There were 2 sources of potential carcinogens in the area. It is concluded that testicular cancer may have developed in these men as a result of exposure to environmental carcinogens.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D004407	Dysgerminoma	A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)	Disgerminoma,Disgerminomas,Dysgerminomas
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D013029	Space-Time Clustering	A statistically significant excess of cases of a disease, occurring within a limited space-time continuum.	Clustering, Space-Time,Clusterings, Space-Time,Space Time Clustering,Space-Time Clusterings
D013736	Testicular Neoplasms	Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.	Cancer of Testis,Cancer of the Testes,Testicular Cancer,Testicular Neoplasm,Testicular Tumor,Testis Cancer,Cancer of the Testis,Neoplasms, Testicular,Neoplasms, Testis,Testicular Tumors,Testis Neoplasms,Tumor of Rete Testis,Cancer, Testicular,Cancer, Testis,Cancers, Testicular,Cancers, Testis,Neoplasm, Testicular,Neoplasm, Testis,Rete Testis Tumor,Rete Testis Tumors,Testicular Cancers,Testis Cancers,Testis Neoplasm,Testis Tumor, Rete,Testis Tumors, Rete,Tumor, Testicular,Tumors, Testicular