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Feeding was induced in rats by electrical stimulation in the lateral hypothalamus. Naloxone (0.2 and 1.0 mg/kg) produced a dose-related elevation of the frequency threshold for stimulation-induced feeding while quarternary naloxone (2.0 and 10.0 mg/kg) had no effect. Since quarternary naloxone does not readily penetrate the blood-brain barrier, we conclude that the opiate receptors at which naloxone exerts its anorectic action are located in the brain rather than in potential peripheral tissues such as gastrointestinal tract, pancreas or adrenal medulla. The threshold-elevating effect of naloxone only became marked after rats had engaged in one or two 5-sec bouts of feeding. The effect continued to increase following each subsequent bout of feeding. Naloxone therefore appears to inhibit feeding by interacting with post-ingestive factors.
K D Carr, and
E J Simon
January 1981,
Proceedings of the Western Pharmacology Society,
K D Carr, and
E J Simon
August 1996,
Pharmacology, biochemistry, and behavior,
K D Carr, and
E J Simon
June 1983,
Neuropharmacology,
K D Carr, and
E J Simon
June 1989,
Presse medicale (Paris, France : 1983),
K D Carr, and
E J Simon
January 2000,
Behavioural brain research,
K D Carr, and
E J Simon
January 1980,
Pharmacology, biochemistry, and behavior,
K D Carr, and
E J Simon
July 1978,
Behavioral biology,
K D Carr, and
E J Simon
April 1985,
Physiology & behavior,
K D Carr, and
E J Simon
March 1981,
Brain research,
K D Carr, and
E J Simon
November 1983,
Fertility and sterility,
