Biomaterial Database

Antagonism of the excitatory effects of 5-hydroxytryptamine on sympathetic preganglionic neurones and neurones activated by visceral afferents. 1983

K Kadzielawa

The responses of electrophysiologically identified sympathetic preganglionic neurones (SPGN) and interneurones activated by sympathetic visceral afferents (VA), to iontophoretic application of 5-hydroxytryptamine (serotonin) and serotonin receptor antagonists: methysergide and cinanserin, were tested in the T3 segment of the spinal cord of the cat. Serotonin had a definite and dose-dependent excitatory action on sympathetic preganglionic neurones and neurones activated by visceral afferents. This excitatory response to serotonin was characterized by the rapid development of tachyphylaxis. Methysergide antagonized the effects of serotonin in preganglionic neurones and neurones activated by visceral afferents. Cinanserin was less effective than methysergide. Preliminary data on the effect of inhibitors of serotonin uptake: chloroimipramine and fluoxetine are also reported. These findings support the idea that the sympathetic output and the activity of neurones activated by sympathetic viscero-afferents is modulated by an excitatory serotoninergic supraspinal input.

UI	MeSH Term	Description	Entries
D007478	Iontophoresis	Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.	Iontophoreses
D008784	Methysergide	An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.	Dimethylergometrin,Methylmethylergonovine,Deseril,Desril,Désernil-Sandoz,Methysergide Dimaleate,Methysergide Maleate,Sansert,UML-491,Dimaleate, Methysergide,Désernil Sandoz,Maleate, Methysergide,UML 491,UML491
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002928	Cinanserin	A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.	Cinanserin Hydrochloride,Cinanserin Monohydrochloride,SQ-10,643,SQ-16,167,Hydrochloride, Cinanserin,Monohydrochloride, Cinanserin,SQ 10,643,SQ 16,167,SQ10,643,SQ16,167
D004594	Electrophysiology	The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
D005260	Female		Females
D005728	Ganglia, Sympathetic	Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.	Celiac Ganglia,Sympathetic Ganglia,Celiac Ganglion,Ganglion, Sympathetic,Ganglia, Celiac,Ganglion, Celiac,Sympathetic Ganglion
D000344	Afferent Pathways	Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.	Afferent Pathway,Pathway, Afferent,Pathways, Afferent
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia