BIOMAT Database Logo BIOMAT Database Logo

Excitation of single sensory neurones in the rat caudal trigeminal nucleus by iontophoretically applied adenosine 5'-triphosphate. 1983

T E Salt, and R G Hill

ATP can be released from the peripheral endings of sensory nerves, and thus may be a neurotransmitter of primary afferent fibres [12]. We have found that ATP is excitatory when applied to single sensory neurones in the rat caudal trigeminal nucleus, and this action is consistent with a neurotransmitter role. However, adenosine monophosphate and pyrophosphate, two metabolites of ATP, were respectively found to be inhibitory and excitatory, and thus it remains unclear whether the actions of ATP are direct or are due to actions of its metabolites.

UI MeSH Term Description Entries
D007478 Iontophoresis Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current. Iontophoreses
D008297 Male Males
D009475 Neurons, Afferent Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM. Afferent Neurons,Afferent Neuron,Neuron, Afferent
D000255 Adenosine Triphosphate An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. ATP,Adenosine Triphosphate, Calcium Salt,Adenosine Triphosphate, Chromium Salt,Adenosine Triphosphate, Magnesium Salt,Adenosine Triphosphate, Manganese Salt,Adenylpyrophosphate,CaATP,CrATP,Manganese Adenosine Triphosphate,MgATP,MnATP,ATP-MgCl2,Adenosine Triphosphate, Chromium Ammonium Salt,Adenosine Triphosphate, Magnesium Chloride,Atriphos,Chromium Adenosine Triphosphate,Cr(H2O)4 ATP,Magnesium Adenosine Triphosphate,Striadyne,ATP MgCl2
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014279 Trigeminal Nucleus, Spinal Nucleus of the spinal tract of the trigeminal nerve. It is divided cytoarchitectonically into three parts: oralis, caudalis (TRIGEMINAL CAUDAL NUCLEUS), and interpolaris. Nucleus, Spinal Trigeminal,Spinal Trigeminal Nucleus
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

T E Salt, and R G Hill
The excitation and depression of hippocampal neurones by iontophoretically applied enkephalins [proceedings].
October 1977, The Journal of physiology,
T E Salt, and R G Hill
Responses of midbrain neurones to iontophoretically applied 5-hydroxytryptamine.
June 1973, British journal of pharmacology,
T E Salt, and R G Hill
A quantitative analysis of the excitation of single cortical neurones by acetylcholine and L-glutamic acid applied micro-iontophoretically.
November 1974, Neuropharmacology,
T E Salt, and R G Hill
Excitation of antidromically identified neurosecretory cells of the paraventricular nucleus by oxytocin applied iontophoretically.
January 1972, Experimental neurology,
T E Salt, and R G Hill
Excitation and inhibition of rat medial vestibular nucleus neurones by 5-hydroxytryptamine.
January 1993, Experimental brain research,
T E Salt, and R G Hill
Proceedings: Antagonism of the effects of iontophoretically applied (+)-amphetamine by chlorpromazine on single neurones.
September 1973, British journal of pharmacology,
T E Salt, and R G Hill
Excitatory effects of adenosine 5'-triphosphate on rat locus coeruleus neurones.
March 1992, European journal of pharmacology,
T E Salt, and R G Hill
Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones.
August 1988, Pflugers Archiv : European journal of physiology,
T E Salt, and R G Hill
A comparison of the responses of cortical neurones to iontophoretically applied tryptamine and 5-hydroxytryptamine in the rat.
March 1982, Neuropharmacology,
T E Salt, and R G Hill
Responses of thalamic neurones to iontophoretically applied drugs.
February 1966, Nature,
Copied contents to your clipboard!